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Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - Apr 19, 2004
Applications Due:

Multiple Receipt Dates - See Link to Full Announcement for details.

total funding: Not Available
max award: none
min award: none
cost sharing, matching: No
number of awards: Not Available
type of funding: Grant

The NIH Institutes listed above invite research grant applications to
conduct studies designed to develop innovative approaches that would
contribute to our understanding of the mechanisms that impact on the
virulence of infections involving two or more microorganisms or strains
of microorganisms (with the exception of HIV). This announcement
encourages investigators to think beyond the one organism-one disease
concept and instead to consider the fact that many diseases are caused
by the synergistic and inhibitory interactions of bacteria, viruses,
parasites, and fungi. Projects should include studies aimed at
understanding the cellular and molecular interactions of pathogens with
the normal flora as well as the interactions among pathogens
themselves, and how commensal organisms can be used to prevent or treat
infections; however, this PA is limited to those projects that involve
or are based on intermicrobial interactions that have been well
documented to occur in clinical settings. In addition, extensive
research is needed on the host responses to polymicrobial infections in
order to develop new approaches to treat and prevent these infections.
The development of co-infection models and the use of genomic and
proteomic technologies to identify common virulence mechanisms and host
response patterns as well as the development of diagnostic and
prognostic microbial/host signature patterns are encouraged. Because of
the complexity of such projects, the establishment of collaborative
scientific teams, both domestic and international, with diverse
scientific disciplines studying polymicrobial diseases, including
microbiology, immunology, biochemistry, clinical medicine, pathology,
bioengineering, material science, imaging technology, and mathematical
modeling are encouraged.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Bioengineering Research
Discovery and Applied Research
Heart and Vascular Diseases Research
Oral Diseases and Disorders Research
Research Related to Deafness and Communication Disorders

More Information:


If you have problems accessing the full announcement, please contact: NIH OER Webmaster

Address Info:

Office of Extramural Programs
6705 Rockledge Drive
Bethesda, MD 20892-7963

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